Emodin Combined with Multiple-Low-Frequency, Low-Intensity Ultrasound To Relieve Osteomyelitis through Sonoantimicrobial Chemotherapy

Author:

Lu Feng12ORCID,Wu Xinhui34,Hu Huiqun25,He Zixuan12,Sun Jiacheng34,Zhang Jiapeng34,Song Xiaoting34,Jin Xiangang12,Chen Guofu4ORCID

Affiliation:

1. Department of Orthopedics, Taizhou Hospital of Zhejiang Province, Zhejiang University, Linhai, China

2. Zhejiang University School of Medicine, Hangzhou, China

3. Wenzhou Medical University, Wenzhou, China

4. Department of Orthopedics, Taizhou Hospital Affiliated with Wenzhou Medical University, Linhai, China

5. Department of Infectious Diseases, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

Abstract

Antibiotic therapy is the first choice for clinical treatment of osteomyelitis, but the formation of bacterial biofilms and the emergence of many drug-resistant strains also create an urgent need to find an alternative treatment to effectively eliminate the infection. Recently, LFLIU has come to be considered a safe and promising method of debridement and antibacterial therapy.

Funder

Hangzhou Municipal Health and Family Planning Commission

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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