Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P-Reference-Cited by-同舟云学术

Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ranjit Dev K.¹,Moye Zachary D.¹,Rocha Fernanda G.¹,Ottenberg Gregory¹,Nichols Frank C.²,Kim Hey-Min¹,Walker Alejandro R.¹^ORCID,Gibson Frank C.¹^ORCID,Davey Mary E.¹^ORCID

Affiliation:

1. Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA

2. Division of Periodontology, University of Connecticut School of Dental Medicine, Farmington, Connecticut, USA

Abstract

Sphingoid base phosphates, such as s phingosine- 1 - p hosphate (S1P) and d i h ydro s phingosine- 1 - p hosphate (dhS1P), act as ligands for S1P receptors, and this interaction is known to play a central role in mediating angiogenesis, vascular stability and permeability, and immune cell migration to sites of inflammation. Studies suggest that a shift in ratio to higher levels of dhS1P in relation to S1P alters downstream signaling cascades due to differential binding and activation of the various S1P receptor isoforms.

Funder

HHS | NIH | National Institute of Dental and Craniofacial Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00002-22

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