Delayed-Type Hypersensitivity Responses to ESAT-6 and MPT64 from Mycobacterium tuberculosis in the Guinea Pig-Reference-Cited by-同舟云学术

Delayed-Type Hypersensitivity Responses to ESAT-6 and MPT64 from Mycobacterium tuberculosis in the Guinea Pig

Published:1998-07 Issue:7 Volume:66 Page:3454-3456
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Elhay Martin J.¹,Oettinger Thomas¹,Andersen Peter¹

Affiliation:

1. Department of TB Immunology, Statens Serum Institut, Copenhagen, Denmark

Abstract

ABSTRACT Two antigens from Mycobacterium tuberculosis , ESAT-6 and MPT64, elicited delayed-type hypersensitivity (DTH) skin responses in outbred guinea pigs infected with M. tuberculosis by the aerosol and intravenous routes but not those sensitized with M. bovis BCG or M. avium . The DTH epitope of ESAT-6 was mapped to the C terminus. Nonresponders to the individual antigens were found, but all animals responded to a combination of ESAT-6 and MPT64 or their respective minimal target peptides. Correspondingly, these molecules could form the basis of a new skin test for tuberculosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.7.3454-3456.1998

Reference22 articles.

1. Amoudy H. A. A. S. Mustafa H. G. Wiker A. T. Abal P. Ravn F. Oftung and P. Andersen. Unpublished data.

2. MPB 64 possesses ‘tuberculosis-complex’-specific B- and T-cell epitopes.;Andersen A. B.;Scand. J. Immunol.,1991

3. Interspecies reactivity of five monoclonal antibodies to Mycobacterium tuberculosis as examined by immunoblotting and enzyme-linked immunosorbent assay

4. Recall of long-lived immunity to Mycobacterium tuberculosis infection in mice.;Andersen P.;J. Immunol.,1995

5. Human T-cell responses to secreted antigen fractions of Mycobacterium tuberculosis

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