Affiliation:
1. Unité des Rickettsies, Faculté de Médecine, Marseille, France.
Abstract
The susceptibilities of 13 isolates of Coxiella burnetii to fusidic acid and ceftriaxone were determined by use of the recently described shell vial assay (D. Raoult, H. Torres, and M. Drancourt, Antimicrob. Agents Chemother, 35:2070-2077, 1991). At a concentration of 4 micrograms/ml, ceftriaxone was bacteriostatic for four isolates and slowed the multiplication of the other nine. Fusidic acid at a concentration of 2 micrograms/ml was bacteriostatic for six isolates and slowed the multiplication of three others. These results show that these compounds could be effective in the phagolysosome of C. burnetii-infected cells.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference30 articles.
1. Communique 1991 du Comite de l'Antibiogramme de la Societe Francaise de;Acar J.;Microbiologie. Pathol. Biol. (Paris),1991
2. Auvergnat J. C. 1990. Personnal communication.
3. Concentrations of fusidic acid, cloxacillin, and cefamandole in sera and atrial appendages of patients undergoing cardiac surgery;Bergeron M. G.;Antimicrob. Agents Chemother.,1985
4. In vitro activity of ciprofloxacin, ceftriaxone, and five other antimicrobial agents against 95 strains of Brucella melitensis;Bosch J.;Antimicrob. Agents Chemother.,1986
5. Fusidic acid in orthopedies;Coombs R. R. H.;Curr. Ther. Res.,1987
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