Ceftolozane-Tazobactam Versus Ceftazidime-Avibactam for the Treatment of Infections Caused by Multidrug-Resistant Pseudomonas aeruginosa: a Multicenter Cohort Study

Author:

Almangour Thamer A.1ORCID,Ghonem Leen2,Alassiri Dareen1,Aljurbua Alanoud1,Al Musawa Mohammed3,Alharbi Aminah3,Almohaizeie Abdullah45,Almuhisen Sara6,Alghaith Jeelan4,Damfu Nader78,Aljefri Doaa97,Alfahad Wafa10,Khormi Yaqoub10,Alanazi Menyfah Q.711,Alsowaida Yazed Saleh12ORCID

Affiliation:

1. Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

2. Clinical Pharmacy Services, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia

3. Pharmaceutical Care Division, King Faisal Specialist Hospital & Research Centre, Jeddah, Saudi Arabia

4. Pharmaceutical Care Division, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia

5. College of Pharmacy, Alfaisal University, Riyadh, Saudi Arabia

6. Pharmacy services administration, King Fahad Medical City, Riyadh, Saudi Arabia

7. King Abdullah International Medical Research Centre, Riyadh, Saudi Arabia

8. Infection Prevention and Control Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia

9. Pharmaceutical Care Department, King Abdul Aziz Medical City, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia

10. Pharmacy services, Prince Sultan Military Medical City, Riyadh, Saudi Arabia

11. King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia

12. Department of Clinical Pharmacy, College of Pharmacy, Hail University, Hail, Saudi Arabia

Abstract

Ceftolozane-tazobactam (C-T) and ceftazidime-avibactam (CAZ-AVI) are two novel antimicrobials that retain activity against resistant Pseudomonas aeruginosa . The comparative effectiveness and safety of C-T versus CAZ-AVI remain unknown.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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