A Novel Family of RNA-Binding Proteins Regulate Polysaccharide Metabolism in Bacteroides thetaiotaomicron-Reference-Cited by-同舟云学术

A Novel Family of RNA-Binding Proteins Regulate Polysaccharide Metabolism in Bacteroides thetaiotaomicron

Published:2021-10-12 Issue:21 Volume:203 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Adams Amanda N. D.¹^ORCID,Azam Muhammad S.¹,Costliow Zachary A.¹,Ma Xiangqian¹,Degnan Patrick H.²,Vanderpool Carin K.¹

Affiliation:

1. Department of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA

2. Department of Microbiology and Plant Pathology, University of California-Riverside, Riverside, California, USA

Abstract

The human colon houses hundreds of bacterial species, including many belonging to the genus Bacteroides , that aid in breaking down our food to keep us healthy. Bacteroides have many genes responsible for breaking down different dietary carbohydrates and complex regulatory mechanisms ensure that specific genes are only expressed when the right carbohydrates are available. In this study, we discovered that Bacteroides use a family of RNA-binding proteins as global regulators to coordinate expression of carbohydrate utilization genes.

Funder

Roy J. Carver Charitable Trust

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00217-21

Reference97 articles.

1. Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans

2. Diet Dominates Host Genotype in Shaping the Murine Gut Microbiota

3. Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes