Synergistic anticryptosporidial potential of the combination alpha-1-antitrypsin and paromomycin-Reference-Cited by-同舟云学术

Synergistic anticryptosporidial potential of the combination alpha-1-antitrypsin and paromomycin

Published:1997-09 Issue:9 Volume:41 Page:2006-2008
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Forney J R¹,Yang S¹,Healey M C¹

Affiliation:

1. Department of Biology, College of Science, Utah State University, Logan 84322-5600, USA.

Abstract

The combined effect of the serine protease inhibitor alpha-1-antitrypsin (AAT) and the aminoglycoside paromomycin on Cryptosporidium parvum infection in vitro was investigated. AAT and paromomycin were mixed with C. parvum oocysts as either single or combined treatments and used to inoculate epithelial cell cultures. Single- and combined-treatment groups had significantly lower (P < 0.01) parasite numbers than untreated controls. The mean fractional inhibitory concentration indices suggested significant synergistic activity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.41.9.2006

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