Enhancement of Acetic Acid Tolerance in Saccharomyces cerevisiae by Overexpression of theHAA1Gene, Encoding a Transcriptional Activator

Abstract

ABSTRACTHaa1 is a transcriptional activator required forSaccharomyces cerevisiaeadaptation to weak acids. Here we show that the constitutiveHAA1-overexpressing strain acquired a higher level of acetic acid tolerance. Under conditions of acetic acid stress, the intracellular level of acetic acid was significantly lower inHAA1-overexpressing cells than in the wild-type cells.