Affiliation:
1. State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao, People’s Republic of China
Abstract
DnaE2 is responsible for bacterial SOS mutagenesis in nearly one-third of sequenced bacterial strains. However, its mechanism, especially the function of its accessory protein ImuA, is still unclear. Here, we report that
M. xanthus
ImuA could affect SOS mutagenesis by inhibiting the recombinase activity of RecA1, which helps to explain the mechanism of DnaE2-dependent TLS and the selection of the two restart pathways to repair the stalled replication fork.
Funder
Key program of Shandong natural science foundation
Key Research and Development Project of Shandong Province
Special National Project on the Investigation of Basic Resources of China
MOST | National Key Research and Development Program of China
National Natural Science Foundation of China
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献