Mechanism of Resistance to Amikacin and Kanamycin in Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Mechanism of Resistance to Amikacin and Kanamycin in Mycobacterium tuberculosis

Published:1998-05 Issue:5 Volume:42 Page:1295-1297
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Alangaden George J.¹,Kreiswirth Barry N.²,Aouad Arlette¹,Khetarpal Minoo¹,Igno Felicitas R.¹,Moghazeh Soraya L.²,Manavathu Elias K.¹,Lerner Stephen A.¹³

Affiliation:

1. Division of Infectious Diseases1 and

2. Public Health Research Institute TB Center, New York, New York 100162

3. Department of Biochemistry and Molecular Biology,3 Wayne State University School of Medicine, Detroit, Michigan 48201, and

Abstract

ABSTRACT An A1400G mutation of the rrs gene was identified in Mycobacterium tuberculosis (MTB) strain ATCC 35827 and in 13 MTB clinical isolates resistant to amikacin-kanamycin (MICs, >128 μg/ml). High-level cross-resistance may result from such a mutation since MTB has a single copy of the rrs gene. Another mechanism(s) may account for high-level amikacin-kanamycin resistance in two mutants and lower levels of resistance in four clinical isolates, all lacking the A1400G mutation.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.5.1295

Reference22 articles.

1. Alangaden G. J. Igno F. R. Zvonok N. M. Manavathu E. K. Lerner S. A. Mechanism(s) of amikacin and streptomycin resistance in Mycobacterium tuberculosis abstr. C136 Program and abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. 1996 58 American Society for Microbiology Washington D.C

2. Amikacin in the treatment of pulmonary tuberculosis.;Allen B. W.;Tubercle,1983

3. Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides.;Beauclerk A. A. D.;J. Mol. Biol.,1987

4. Characterization of streptomycin resistance mechanisms among Mycobacterium tuberculosis isolates from patients in New York City

5. Mutations in 16S ribosomal RNA disrupt antibiotic-RNA interactions.;DeStasio E. A.;EMBO J.,1989

Cited by 170 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Brevicidine acts as an effective sensitizer of outer membrane-impermeable conventional antibiotics for Acinetobacter baumannii treatment;Frontiers in Microbiology;2023-12-15

2. Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea;Antibiotics;2023-08-17

3. Study of Structurally Diverse Currently Used and Recently Developed Antimycobacterial Drugs;Medicinal Chemistry;2023-08

4. Heterologous production of the D-cycloserine intermediate O-acetyl-L-serine in a human type II pulmonary cell model;Scientific Reports;2023-05-26

5. Molecular Mechanisms of MmpL3 Function and Inhibition;Microbial Drug Resistance;2023-05-01