Antibacterial Activities and Inhibitory Effects of Sitafloxacin (DU-6859a) and Its Optical Isomers against Type II Topoisomerases-Reference-Cited by-同舟云学术

Antibacterial Activities and Inhibitory Effects of Sitafloxacin (DU-6859a) and Its Optical Isomers against Type II Topoisomerases

Published:1998-05 Issue:5 Volume:42 Page:1284-1287
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Akasaka Takaaki¹,Kurosaka Seiko¹,Uchida Yoko¹,Tanaka Mayumi¹,Sato Kenichi¹,Hayakawa Isao¹

Affiliation:

1. New Product Research Laboratories I, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan

Abstract

ABSTRACT The in vitro inhibitory effects of sitafloxacin (DU-6859a) and its three stereoisomers on bacterial DNA gyrase from Escherichia coli , topoisomerase IV from Staphylococcus aureus , and topoisomerase II from human placenta were compared. No correlation was observed between the inhibitory activities of quinolones against bacterial type II topoisomerases and those against human topoisomerase II. Sitafloxacin showed the most potent inhibitory activities against bacterial type II topoisomerases and the lowest activity against human type II topoisomerase.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.42.5.1284

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