New Perspectives on Antimicrobial Agents: Long-Acting Lipoglycopeptides

Author:

Tran Truc T.12ORCID,Gomez Villegas Sara12,Aitken Samuel L.3ORCID,Butler-Wu Susan M.4ORCID,Soriano Alex5,Werth Brian J.6ORCID,Munita Jose M.78ORCID

Affiliation:

1. Center for Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA

2. Division of Infectious Diseases, Houston Methodist Hospital, Houston, Texas, USA

3. Department of Pharmacy, University of Michigan Health, Ann Arbor, Michigan, USA

4. Department of Pathology, Keck School of Medicine of USC, Los Angeles, California, USA

5. Department of Infectious Diseases, Hospital Clinic of Barcelona, Barcelona, Spain

6. University of Washington School of Pharmacy, Seattle, Washington, USA

7. Millennium Initiative for Collaborative Research On Bacterial Resistance (MICROB-R), Santiago, Chile

8. Genomics & Resistant Microbes (GeRM) Group, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Santiago, Chile

Abstract

The long-acting lipoglycopeptides (LGPs) dalbavancin and oritavancin are semisynthetic antimicrobials with broad and potent activity against Gram-positive bacterial pathogens. While they are approved by the Food and Drug Administration for acute bacterial skin and soft tissue infections, their pharmacological properties suggest a potential role of these agents for the treatment of deep-seated and severe infections, such as bloodstream and bone and joint infections.

Funder

HHS | National Institutes of Health

Pfizer

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference112 articles.

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