Coxiella burnetii Intratracheal Aerosol Infection Model in Mice, Guinea Pigs, and Nonhuman Primates-Reference-Cited by-同舟云学术

Coxiella burnetii Intratracheal Aerosol Infection Model in Mice, Guinea Pigs, and Nonhuman Primates

Published:2019-12 Issue:12 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Gregory A. E.¹,van Schaik E. J.¹,Russell-Lodrigue K. E.²,Fratzke A. P.¹,Samuel J. E.¹

Affiliation:

1. Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, Texas, USA

2. Tulane University, School of Medicine, Tulane National Primate Research Center, Covington, Louisiana, USA

Abstract

Coxiella burnetii , the etiological agent of Q fever, is a Gram-negative bacterium transmitted to humans by inhalation of contaminated aerosols. Acute Q fever is often self-limiting, presenting as a febrile illness that can result in atypical pneumonia. In some cases, Q fever becomes chronic, leading to endocarditis that can be life threatening. The formalin-inactivated whole-cell vaccine (WCV) confers long-term protection but has significant side effects when administered to presensitized individuals.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

DOD | Defense Threat Reduction Agency

Tulane University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00178-19

Reference59 articles.

1. Murine Alveolar Macrophages Are Highly Susceptible to Replication of Coxiella burnetii Phase II In Vitro