Herpes Simplex Virus Entry Mediator Associates in Infected Cells in a Complex with Viral Proteins gD and at Least gH-Reference-Cited by-同舟云学术

Herpes Simplex Virus Entry Mediator Associates in Infected Cells in a Complex with Viral Proteins gD and at Least gH

Published:2005-04 Issue:7 Volume:79 Page:4540-4544
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Perez-Romero Pilar¹,Perez Aleida¹,Capul Althea¹,Montgomery Rebecca²,Fuller A. Oveta³

Affiliation:

1. Department of Microbiology and Immunology

2. Institute for Molecular Virology, University of Wisconsin, Madison, Wisconsin

3. Program in Cellular and Molecular Biology, School of Medicine, University of Michigan, Ann Arbor, Michigan

Abstract

ABSTRACT We examined herpes simplex virus (HSV)-infected human HEp-2 cells or porcine cells that express herpes virus entry mediator (HVEM) for virus and receptor protein interactions. Antibody to HVEM, or its viral ligand gD, coimmunoprecipitated several similar proteins. A prominent 110-kDa protein that coprecipitated was identified as gH. The HVEM/gD/gH complex was detected with mild or stringent cell lysis conditions. It did not form in cells infected with HSV-1(KOS)Rid1 virus or with null virus lacking gD, gH, or gL. Thus, in cells a complex forms through physical associations of HVEM, gD, and at least gH.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.79.7.4540-4544.2005

Reference40 articles.

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