Generation and Evaluation of a Glaesserella (Haemophilus) parasuis Capsular Mutant-Reference-Cited by-同舟云学术

Generation and Evaluation of a Glaesserella (Haemophilus) parasuis Capsular Mutant

Published:2020-04-20 Issue:5 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Eberle Kirsten C.¹,Hau Samantha J.¹,Luan Shi-Lu²,Weinert Lucy A.²,Stasko Judith A.¹,Wang Jinhong²,Peters Sarah E.²,Langford Paul R.³^ORCID,Rycroft Andrew N.⁴,Wren Brendan W.⁵,Maskell Duncan J.²,Tucker Alexander W.²,Brockmeier Susan L.¹

Affiliation:

1. National Animal Disease Center, Agricultural Research Service, USDA, Ames, Iowa, USA

2. Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom

3. Section of Paediatric Infectious Disease, Department of Infectious Disease, Imperial College London, St. Mary’s Campus, London, United Kingdom

4. The Royal Veterinary College, Hawkshead Campus, Hatfield, United Kingdom

5. Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

Abstract

Glaesserella ( Haemophilus ) parasuis is a commensal bacterium of the upper respiratory tract in pigs and also the causative agent of Glässer’s disease, which causes significant morbidity and mortality in pigs worldwide. Isolates are characterized into 15 serovars by their capsular polysaccharide, which has shown a correlation with isolate pathogenicity. To investigate the role the capsule plays in G. parasuis virulence and host interaction, a capsule mutant of the serovar 5 strain HS069 was generated (HS069Δcap) through allelic exchange following natural transformation.

Funder

Wellcome Trust

UK Research and Innovation | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00879-19

Reference32 articles.

1. Aragon V, Segales J, Oliveira S. 2012. Glasser’s disease, p 760–769. In Zimmerman JJ, Karriker LA, Ramirez A, Schwartz KJ, Stevenson GW (ed), Diseases of swine, 10th ed. John Wiley & Sons, Inc, West Sussex, United Kingdom.

2. Phylogenomic analysis of Haemophilus parasuis and proposed reclassification to Glaesserella parasuis, gen. nov., comb. nov.

3. Designation of 15 serovars of Haemophilus parasuis on the basis of immunodiffusion using heat-stable antigen extracts

4. Development of a Multiplex PCR Assay for Rapid Molecular Serotyping of Haemophilus parasuis

5. Correlation between clinico-pathological outcome and typing of Haemophilus parasuis field strains

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Salmonella enterica serovar Choleraesuis vector outperforms alum as an adjuvant, increasing a cross-protective immune response against Glaesserella parasuis;Veterinary Microbiology;2023-12

2. Larval settlement and metamorphosis of Mytilus coruscus in response to varying bacterial capsular polysaccharide;Frontiers in Marine Science;2023-01-23

3. Other Pasteurellaceae:Avibacterium,Bibersteinia,Gallibacterium,Glaesserella, andHistophilus;Pathogenesis of Bacterial Infections in Animals;2022-08-19

4. Glässer's disease;CABI Compendium;2022-01-07

5. Replication of Streptococcus equi subspecies zooepidemicus infection in swine;Veterinary Microbiology;2022-01