Characterization of Three Staphylococcus aureus Isolates from a 17-Year-Old Female Who Died of Tampon-Related Toxic Shock Syndrome

Author:

Tang Yi-Wei12,Himmelfarb Eric1,Wills Marcia1,Stratton Charles W.12

Affiliation:

1. Departments of Pathology

2. Medicine, Vanderbilt University Medical Center, Nashville, Tennessee

Abstract

ABSTRACT We report the identification and characterization of three Staphylococcus aureus isolates recovered from throat and vaginal cultures, as well as from an axillary abscess, of a 17-year-old female who died of tampon-related toxic shock syndrome. The three S. aureus isolates were unrelated as determined by pulsed-field gel electrophoresis. The vaginal isolate was mecA , Panton-Valentine leukocidin, and staphylococcal enterotoxin B and C negative, toxic shock syndrome toxin 1 positive, and staphylococcal cassette chromosome mec element (SCC mec ) untypeable, which was consistent with the clinical and autopsy findings that death was due to tampon-related toxic shock syndrome.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference15 articles.

1. Blair, J. D., D. G. Livingston, and R. Vongsnichakul. 1982. Tampon-related toxic-shock syndrome. Histopathologic and clinical findings in a fatal case. Am. J. Clin. Pathol.78:372-376.

2. Blomster-Hautamaa, D. A., B. N. Kreiswirth, J. S. Kornblum, R. P. Novick, and P. M. Schlievert. 1986. The nucleotide and partial amino acid sequence of toxic shock syndrome toxin-1. J. Biol. Chem.261:15783-15786.

3. Boyle-Vavra, S., and R. S. Daum. 2007. Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin. Lab. Invest.87:3-9.

4. Exotoxins of Staphylococcus aureus

5. Herzer, C. M. 2001. Toxic shock syndrome: broadening the differential diagnosis. J. Am. Board Fam. Pract.14:131-136.

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