Affiliation:
1. National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China
2. Yunnan Provincial Centre for Disease Control and Prevention, Kunming, China
Abstract
ABSTRACT
Brucella abortus
and
Yersinia enterocolitica
serotype O:9 serologically cross-react in the immune response with the host; therefore, our aim was to compare the immune responses to these two pathogens. We selected typical
B. abortus
and
Y. enterocolitica
O:9 strains to study the cytokine immune response and the histopathological changes in livers and spleens of BALB/c mice. The data showed the cytokine responses to the two strains of pathogens were different, where the average levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), gamma interferon (IFN-γ), interleukin-12 (IL-12), and tumor necrosis factor alpha (TNF-α) were higher with
B. abortus
infections than with
Y. enterocolitica
O:9 infections, especially for IFN-γ, while the IL-10 level was lower and the levels of IL-1β, IL-4, IL-5, and IL-6 were similar. The histopathological effects in the livers and spleens of the BALB/c mice with
B. abortus
and
Y. enterocolitica
O:9 infections were similar; however, the pathological changes in the liver were greater with
B. abortus
infections, while damage in the spleen was greater with
Y. enterocolitica
O:9 infections. These observations show that different cytokine responses and histopathological changes occur with
B. abortus
and
Y. enterocolitica
O:9 infections.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Cited by
13 articles.
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