“Pathogen Eradication” and “Emerging Pathogens”: Difficult Definitions in Cystic Fibrosis-Reference-Cited by-同舟云学术

“Pathogen Eradication” and “Emerging Pathogens”: Difficult Definitions in Cystic Fibrosis

Published:2018-09 Issue:9 Volume:56 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Gilligan Peter H.¹²,Downey Damian G.³⁴,Elborn J. Stuart⁴⁵⁶,Flume Patrick A.⁷⁸,Funk Sebastian⁹,Gilpin Deirdre¹⁰,Kidd Timothy J.⁴¹¹,McCaughan John¹²,Millar B. Cherie⁴¹³,Murphy Philip G.¹⁴¹⁵,Rendall Jacqueline C.³,Tunney Michael M.¹⁰,Moore John E.⁴¹³

Affiliation:

1. Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

2. Clinical Microbiology-Immunology Laboratories, UNC Health Care, Chapel Hill, North Carolina, USA

3. Northern Ireland Regional Adult CF Centre, Belfast Health and Social Trust, Belfast, Northern Ireland, United Kingdom

4. Centre for Experimental Medicine, Queen's University, Belfast, Northern Ireland, United Kingdom

5. Imperial College, London, United Kingdom

6. Royal Brompton Hospital, London, United Kingdom

7. Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA

8. Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina, USA

9. Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, The London School of Hygiene & Tropical Medicine, London, United Kingdom

10. School of Pharmacy, Queen's University, Belfast, United Kingdom

11. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia

12. Department of Medical Microbiology, The Royal Group of Hospitals, Belfast Health and Social Trust, Belfast, Northern Ireland, United Kingdom

13. Northern Ireland Public Health Laboratory, Belfast City Hospital, Belfast, Northern Ireland, United Kingdom

14. Department of Medical Microbiology, Adelaide and Meath Hospital, Tallaght, Dublin, Ireland

15. School of Medicine, Trinity College, Dublin, Ireland

Abstract

Infection is a common complication of cystic fibrosis (CF) airway disease. Current treatment approaches include early intervention with the intent to eradicate pathogens in the hope of delaying the development of chronic infection and the chronic use of aerosolized antibiotics to suppress infection.

Funder

Vertex Pharmaceuticals

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00193-18

Reference59 articles.

1. Emerging bacterial pathogens and changing concepts of bacterial pathogenesis in cystic fibrosis

2. Effectiveness of a stepwise Pseudomonas aeruginosa eradication protocol in children with cystic fibrosis

3. Cystic fibrosis