Escherichia coli ST131 Associated with Increased Mortality in Bloodstream Infections from Urinary Tract Source

Author:

Brumwell Amanda1,Sutton Granger23,Lantos Paul M.14,Hoffman Kate5,Ruffin Felicia1,Brinkac Lauren2,Clarke Thomas H.2,Adams Mark D.26ORCID,Fowler Vance G.17,Fouts Derrick E.2ORCID,Thaden Joshua T.1ORCID

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA

2. J. Craig Venter Institute, Rockville, Maryland, USA

3. Noblis, Inc., Washington, DC, USA

4. Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA

5. Nicholas School of the Environment, Duke University, Durham, North Carolina, USA

6. The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA

7. Clinical Research Institute, Durham, North Carolina, USA

Abstract

Escherichia coli sequence type 131 (ST131) is a globally dominant multidrug-resistant clone, although its clinical impact on patients with bloodstream infection (BSI) is incompletely understood. This study aims to further define the risk factors, clinical outcomes, and bacterial genetics associated with ST131 BSI.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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