Affiliation:
1. Department of Microbiology, University of Minnesota, Minneapolis, Minnesota 55455
Abstract
The immunogenicity of leptospiral whole cell (WC) and outer envelope (OE) vaccines from virulent and avirulent strains was compared in hamsters. The 50% protective dose against death (PD
50D
) and kidney infection (PD
50K
) was evaluated for serotypes
icterohaemorrhagiae, canicola, pomona
, and
grippotyphosa.
The OE and WC of virulent strains possessed greater immunogenicity than the OE and WC of avirulent strains. More vaccine (<0.1 to 11.0 μg [dry weight] per hamster) was required for the PD
50K
than for the PD
50D
(<0.1 to 1.7 μg [dry weight] per hamster). The OE from virulent strains of these four serotypes plus
hardjo
were combined to form a pentavalent OE vaccine which proved to be satisfactory in immunogenic potency. Duration of immunity was not evaluated.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference11 articles.
1. Anderson D. L. and R. C. Johnson. 1968. Electron microscopy of immune disruption of leptospires: action of complement and lysozyme. 95:2293-2309.
2. J. Bacteriol.
3. Isolation of the outer sheath of Leptospira and its immunogenic properties in hamsters;Auran N. E.;Infect. Immunity,1972
4. Comparative tests with formalized and irradiated vaccines against leptospirosis;Babuderi B.;Bull. WHO,1973
5. An improved leptospiral bacterin for control of bovine leptospirosis;Brown A. L.;Proc. U. S. Livestock Sanit. Ass.,1954
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