Mycobacterium tuberculosis Complex and Mycobacterial Heat Shock Proteins in Lymph Node Tissue from Patients with Pulmonary Sarcoidosis

Author:

Dubaniewicz Anna1,Dubaniewicz-Wybieralska Mirosława2,Sternau Adam3,Zwolska Zofia4,Iżycka-Świeszewska Ewa5,Augustynowicz-Kopeć Ewa4,Skokowski Jarosław6,Singh Mahavir7,Zimnoch Lech4

Affiliation:

1. Department of Pathophysiology, Medical University of Gdansk, Gdansk, Poland

2. Department of Radiology, Medical University of Gdansk, Gdansk, Poland

3. Department of Thoracic Surgery, Medical University of Gdansk, Gdansk, Poland

4. National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland

5. Department of Pathomorphology, Medical University of Gdansk, Gdansk, Poland

6. Department of Surgical Oncology, Medical University of Gdansk, Gdansk, Poland

7. LIONEX Diagnostics and Therapeutics GmbH and GBF, Braunschweig, Germany

Abstract

ABSTRACT We demonstrated that not whole Mycobacterium tuberculosis but its particular antigens, hsp70 Mtb , hsp65 Mtb , and hsp16 Mtb , are present in lymph node tissues of patients with sarcoidosis (SA). hsp16 Mtb occurs in the early stage of SA, whereas hsp70 Mtb occurs in stage II of SA. hsp65 Mtb is highly expressed in the capillary vessels in lymph node tissues in patients with SA.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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