Pasteurella haemolytica leukotoxin enhances production of leukotriene B4 and 5-hydroxyeicosatetraenoic acid by bovine polymorphonuclear leukocytes

Author:

Henricks P A1,Binkhorst G J1,Drijver A A1,Nijkamp F P1

Affiliation:

1. Department of Pharmacology, Faculty of Pharmacy, University of Utrecht, The Netherlands.

Abstract

The influence of the leukotoxin of Pasteurella haemolytica on the generation of arachidonic acid metabolites by bovine polymorphonuclear leukocytes (PMNs) was investigated. PMNs released 5-, 12-, and 15-hydroxyeicosatetraenoic acids (5-, 12-, and 15-HETE) and leukotriene B4 (LTB4) upon stimulation with arachidonic acid. The leukotoxin preparations dose dependently enhanced the release of the 5-lipoxygenase products 5-HETE and LTB4 in arachidonic acid-stimulated PMNs, whereas the release of 12- and 15-HETE was not affected. The enhanced release of LTB4 and 5-HETE was not due to a decreased cellular retention of the 5-lipoxygenase products. In addition, leukotoxin preparations by themselves were also able to induce LTB4 and 5-HETE production in the absence of exogenous arachidonic acid. Generation of 5-lipoxygenase products by PMNs stimulated by leukotoxin may represent an important cellular event that occurs during infections with P. haemolytica.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference49 articles.

1. Adlam C. 1989. The structure function and properties of cellular and extracellular components of Pasteurella haemolytica p. 75-92. In C. Adlam and J. M. Rutter (ed.) Pasteurella and pasteurellosis. Academic Press Inc. (London) Ltd. London.

2. Sequential lesions of experimental bovine pneumonic pasteurellosis;Allan E. M.;Vet. Rec.,1985

3. Interaction of Pasteurella haemolytica with bovine neutrophils: identification and partial characterization of a cytotoxin;Baluyut C. S.;Am. J. Vet. Res.,1981

4. Cytotoxic effects of Pasteurella haemolytica on bovine neutrophils;Berggren K. A.;Am. J. Vet. Res.,1981

5. Potent leukocidal action of Eschenchia coli hemolysin mediated by permeabilization of target cell membranes;Bhakdi S.;J. Exp. Med.,1989

Cited by 39 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Mannheimia;Bergey's Manual of Systematics of Archaea and Bacteria;2020-06

2. RESPIRATORY TRACT INFECTIONS IN CATTLE;Scientific and Technical Bulletin оf State Scientific Research Control Institute of Veterinary Medical Products and Fodder Additives аnd Institute of Animal Biology;2020-06-01

3. Mannheimia;Bergey's Manual of Systematics of Archaea and Bacteria;2015-09-14

4. Anti-inflammatory effects of retinoids and carotenoid derivatives on caspase-3–dependent apoptosis and efferocytosis of bovine neutrophils;American Journal of Veterinary Research;2014-12

5. Direct and Indirect Anti-Inflammatory Effects of Tulathromycin in Bovine Macrophages: Inhibition of CXCL-8 Secretion, Induction of Apoptosis, and Promotion of Efferocytosis;Antimicrobial Agents and Chemotherapy;2013-01-07

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3