Enhanced downregulation of Lck-mediated signal transduction by a Y114 mutation of herpesvirus Saimiri tip-Reference-Cited by-同舟云学术

Enhanced downregulation of Lck-mediated signal transduction by a Y114 mutation of herpesvirus Saimiri tip

Published:1997-09 Issue:9 Volume:71 Page:7092-7096
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Guo J¹,Duboise M¹,Lee H¹,Li M¹,Choi J K¹,Rosenzweig M¹,Jung J U¹

Affiliation:

1. Department of Microbiology and Molecular Genetics, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772-9102, USA.

Abstract

Tip of herpesvirus saimiri associates with Lck and downregulates Lck function in cellular signal transduction. In this report, we demonstrate that mutation of tyrosine 114 of Tip significantly increases Lck-binding activity. This mutant exhibits a dramatic increase in the suppression of cellular tyrosine phosphorylation and surface expression of lymphocyte antigens in comparison with wild-type Tip. In addition, the expression of TipY114 converted the transforming morphology of fibroblasts induced by oncogenic F505 Lck to a normal cellular morphology. These results further support a mechanism by which the association of Tip with Lck negatively regulates Lck-mediated signal transduction.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.71.9.7092-7096.1997

Reference32 articles.

1. Molecular piracy of mammalian interleukin-8 receptor type B by herpesvirus saimiri;Ahuja S. K.;J. Biol. Chem.,1996

2. Primary structure of the herpesvirus saimiri genome;Albrecht J.;J. Virol.,1992

3. Herpesvirus saimiri has a gene specifying a homologue of the cellular membrane glycoprotein CD59;Albrecht J.;Virology,1992

4. The divergence between two oncogenic herpesvirus saimiri strains in a genomic region related to the transforming phenotype;Biesinger B.;Virology,1990

5. The product of the herpesvirus saimiri ORF1 (Tip) interacts with T cell specific kinase p56lck in transformed cells;Biesinger B.;J. Biol. Chem.,1995

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