Substantial Attenuation of Virulence of Tembusu Virus Strain PS Is Determined by an Arginine at Residue 304 of the Envelope Protein

Author:

Yang Lixin1,Liang Te12,Lv Junfeng1,Qu Shenghua1,Meng Runze1,Yang Baolin1,Feng Chonglun1,Dai Weiqian1,Wang Xiaoyan1,Zhang Bing1,Zhang Dabing1ORCID

Affiliation:

1. Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing, People’s Republic of China

2. State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China

Abstract

TMUV-related disease emerged in 2010 and has a significant economic impact on the duck industry. Although the disease was originally recognized to affect adult ducks, increasing evidence has shown that TMUV also causes severe disease of young ducklings.

Funder

China Agricultural Research System

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference52 articles.

1. Tembusu-Related Flavivirus in Ducks, Thailand

2. Zhang D. 2017. Tembusu virus infection in ducks, p 610–613. In Brugère-Picoux XJ, Vaillancourt J-P, Shrivaprasad HL, Venne D, Bouzouala M (ed), Manual of poultry diseases. Association francaise pour I'avancement des sciences (AFAS) Press, Paris, France.

3. Pathogenesis of Thai duck Tembusu virus in Cherry Valley ducks: The effect of age on susceptibility to infection

4. Tembusu Virus in Ducks, China

5. Duck Egg-Drop Syndrome Caused by BYD Virus, a New Tembusu-Related Flavivirus

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