Affiliation:
1. Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, Mississippi, USA
Abstract
Findings from this study define the mechanism of regulation of capsule production in
Staphylococcus aureus
. Specifically, we show that two key regulators, MsaB and CodY, coordinate their functions to control the expression of capsule in response to nutrients.
S. aureus
fine-tunes the production of capsule by coordinating the activity of several regulators and by sensing nutrient levels. This study demonstrates the importance of incorporating multiple inputs prior to the expression of costly virulence factors, such as capsule.
Funder
HHS | NIH | National Institute of General Medical Sciences
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
14 articles.
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