Affiliation:
1. Department of Applied Biological Sciences, Massachusetts Institute of Technology, Cambridge 02139.
Abstract
Previously characterized mutants of Bacillus subtilis 168 were analyzed for the accumulation of the antibiotic bacilysin in culture broths and for the presence of bacilysin synthetase in cell extracts. All aro mutants tested were deficient in bacilysin biosynthesis but had synthetase activity. Mutants with lesions in tyrA and pheA produced normal levels of bacilysin, suggesting that prephenate is the primary metabolic precursor of bacilysin.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
33 articles.
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