Streptococcus pneumoniae Pilus Subunits Protect Mice against Lethal Challenge-Reference-Cited by-同舟云学术

Streptococcus pneumoniae Pilus Subunits Protect Mice against Lethal Challenge

Published:2007-02 Issue:2 Volume:75 Page:1059-1062
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Gianfaldoni Claudia¹,Censini Stefano¹,Hilleringmann Markus¹,Moschioni Monica¹,Facciotti Claudia¹,Pansegrau Werner¹,Masignani Vega¹,Covacci Antonello¹,Rappuoli Rino¹,Barocchi Michèle Anne¹,Ruggiero Paolo¹

Affiliation:

1. Novartis Vaccines and Diagnostics s.r.l., Research Center, Siena, Italy

Abstract

ABSTRACT Streptococcus pneumoniae is a major public health threat worldwide. The recent discovery that this pathogen possesses pili led us to investigate their protective abilities in a mouse model of intraperitoneal infection. Both active and passive immunization with recombinant pilus subunits afforded protection against lethal challenge with the S. pneumoniae serotype 4 strain TIGR4.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.01400-06

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