Radicicol Inhibits Chikungunya Virus Replication by Targeting Nonstructural Protein 2-Reference-Cited by-同舟云学术

Radicicol Inhibits Chikungunya Virus Replication by Targeting Nonstructural Protein 2

Published:2021-06-17 Issue:7 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Nam Sangwoo¹²,Ga Yun Ji³,Lee Joo-Youn⁴,Hwang Woo-Yeon⁴⁵,Jung Eunhye⁴,Shin Jin Soo⁴,Chen Weiyi⁶,Choi Gildon¹⁴,Zhou Bin⁷^ORCID,Yeh Jung-Yong³,Go Yun Young⁶^ORCID

Affiliation:

1. Medicinal Chemistry and Pharmacology, University of Science and Technology, Daejeon, Republic of Korea

2. Molecular Diagnostic Division, Bioneer Corporation, Daejeon, Republic of Korea

3. Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon National University, Incheon, Republic of Korea

4. Therapeutics and Biotechnology Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea

5. Department of Pharmaceutical Science, Kyunghee University, Seoul, Republic of Korea

6. Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine, City University of Hong Kong, Hong Kong SAR, China

7. MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China

Abstract

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes a debilitating febrile illness characterized by persistent muscle and joint pain. The widespread distribution of transmission-competent vectors, Aedes species mosquitoes, indicates the potential risk of large-scale epidemics with high attack rates that can severely impact public health globally.

Funder

City University of Hong Kong

Korea Research Institute of Chemical Technology

Incheon National University Research Grant, 2016

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00135-21

Reference52 articles.

1. The alphaviruses: gene expression, replication, and evolution