Limited Protection Conferred by a DNA Vaccine against a Lethal Pseudorabies Virus Infection at Day 5 Postvaccination-Reference-Cited by-同舟云学术

Limited Protection Conferred by a DNA Vaccine against a Lethal Pseudorabies Virus Infection at Day 5 Postvaccination

Published:2007-04 Issue:4 Volume:14 Page:470-473
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Dory Daniel¹²,Torché Anne-Marie¹²,Béven Véronique¹²,Cariolet Roland¹²,Jestin André¹²

Affiliation:

1. Viral Genetics and Biosafety Unit, French Food Safety Agency (Afssa), Fr-22440 Ploufragan, France

2. Healthy Pigs Production and Experimentation Section, Afssa, Fr-22440 Ploufragan, France

Abstract

ABSTRACT No pseudorabies virus (PRV)-specific neutralizing or immunoglobulin G1-type antibodies were detected in sera 5 days after injection of a DNA vaccine against PRV infection in pigs. PRV-stimulated peripheral blood mononuclear cells produced gamma interferon mRNA in vitro. Two out of five pigs recovered from lethal PRV infection without attenuation of nasal viral excretion.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00428-06

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