Inhibition of Clostridium perfringens by an Antibiotic Substance Produced by Bacillus licheniformis in the Digestive Tract of Gnotobiotic Mice: Effect on Other Bacteria from the Digestive Tract

Author:

Ducluzeau R.1,Dubos F.,Raibaud P.,Abrams G. D.

Affiliation:

1. Laboratoire d'Ecologie Microbienne I.N.R.A., 78350 Jouy-en-Josas, France

Abstract

A strain of Bacillus licheniformis , established in the digestive tract of gnotobiotic mice, inhibited the subsequent establishment of a Clostridium perfringens strain ingested by the animals. This inhibitory effect depended on the in vivo production by B. licheniformis of an antibiotic substance having a number of the characteristics of bacitracin. If C. perfringens was the first to become established in the digestive tract of the gnotobiotic mice, B. licheniformis also became established but did not produce any antibiotic. Mutants of C. perfringens resistant to the antibiotic substance were not observed when the antibiotic was produced in situ by B. licheniformis , but were rapidly selected when the Bacillus culture filtrate or bacitracin was administered per os. B. licheniformis was also capable of eliminating from the digestive tract 5 of the 13 additional bacterial strains tested.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference8 articles.

1. Bacitracin: methods of production, concentration, and partial purification, with a summary of the chemical properties of crude bacitracin;Anker S. H.;J. Bacteriol.,1947

2. Bacitracin biosynthesis and spore formation: the physiological role of an antibiotic;Bernlohr R. W.;Arch. Biochem. Biophys.,1963

3. Ducluzeau R. M. Bellier and P. Raibaud. 1970. Transit digestif de divers inoculums bacteriens introduits "per 25

4. Effet de l'ingestion de doses varibee d'antibiotiques sur la microflore de souris "gnotoxeniques;Ducluzeau R.;Ann. Inst. Pasteur Paris,1971

5. Ensemencement d'une souche Iysogbne et d'une souche sensible d'Escherichia coli K 12 dans le tube digestif de souris ax 6niques: etablissement d'un 6quilibre;Ducluzeau R.;Ann. Inst. Pasteur Paris,1967

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