Variability in the Responses of Hepatitis B Virus D-Subgenotypes to Antiviral Therapy: Designing Pan-D-Subgenotypic Reverse Transcriptase Inhibitors-Reference-Cited by-同舟云学术

Variability in the Responses of Hepatitis B Virus D-Subgenotypes to Antiviral Therapy: Designing Pan-D-Subgenotypic Reverse Transcriptase Inhibitors

Published:2022-01-26 Issue:2 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Khatun Mousumi¹,Kumar Krishna²,Baidya Ayana¹,Mondal Rajiv Kumar¹,Baszczyňski Ondřej³,Kalčic Filip³,Banerjee Soma¹,Dhali Gopal Krishna⁴,Das Kausik⁵,Chowdhury Abhijit⁵,Janeba Zlatko³,Chakrabarti Saikat²,Datta Simanti¹

Affiliation:

1. Centre for Liver Research, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India

2. Structural Biology and Bioinformatics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India

3. Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic

4. Department of Gastroenterology, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India

5. Department of Hepatology, School of Digestive and Liver Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India

Abstract

Current treatment of chronic hepatitis B relies heavily on nucleotide/nucleoside analogs in particular, tenofovir disoproxil fumarate (TDF) and entecavir (ETV) to keep HBV replication under control and prevent end-stage liver diseases. However, it was unclear whether the therapeutic effects of TDF/ETV differ among patients infected with different HBV genotypes and subgenotypes.

Funder

Department of Biotechnology, Ministry of Science and Technology

Department of Higher Education, Science, Technology and Biotechnology, Government of West Bengal

Indian Council of Medical Research

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01800-21

Reference43 articles.

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