Characterization of Megabat-Favored, CA-Dependent Susceptibility to Retrovirus Infection

Author:

Ohkura Sadayuki1ORCID,Horie Masayuki23,Shimizu Masumi1,Nakagawa So4ORCID,Osanai Haruka5,Miyagawa Yoshitaka6,Morita Rimpei1

Affiliation:

1. Department of Microbiology and Immunology, Nippon Medical School, Tokyo, Japan

2. Graduate School of Veterinary Science, Osaka Metropolitan University, Osaka, Japan

3. Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University, Osaka, Japan

4. Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan

5. Department of Medicine, Nippon Medical School, Tokyo, Japan

6. Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan

Abstract

Recent studies have demonstrated the circulation of gammaretroviruses among megabats in Australia and the bats’ resistance to HIV-1 infection; however, the origins of these viruses in megabats and the contribution of bats to retrovirus spread to other mammalian species remains unclear. To determine the intrinsic susceptibility of bat cells to HIV-1 infection, we investigated 12 cell lines isolated from 11 bat species.

Funder

MEXT | Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Capsid-dependent lentiviral restrictions;Journal of Virology;2024-04-16

2. Antiviral effects of interferon-stimulated genes in bats;Frontiers in Cellular and Infection Microbiology;2023-08-18

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