Treatment with Granulocyte-Macrophage Colony-Stimulating Factor Reduces Viral Titers in the Brains of West Nile Virus-Infected Mice and Improves Survival-Reference-Cited by-同舟云学术

Treatment with Granulocyte-Macrophage Colony-Stimulating Factor Reduces Viral Titers in the Brains of West Nile Virus-Infected Mice and Improves Survival

Published:2023-03-30 Issue:3 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Stonedahl Sarah¹²^ORCID,Leser J. Smith³,Clarke Penny³,Potter Huntington³⁴⁵,Boyd Timothy D.⁴⁵,Tyler Kenneth L.³⁶⁷^ORCID

Affiliation:

1. Department of Immunology, University of Colorado, Aurora, Colorado, USA

2. Department of Microbiology, University of Colorado, Aurora, Colorado, USA

3. Department of Neurology, University of Colorado, Aurora, Colorado, USA

4. University of Colorado Alzheimer’s and Cognition Center, Aurora, Colorado, USA

5. Linda Crnic Institute for Down Syndrome, Aurora, Colorado, USA

6. Division of Infectious Disease, Department of Medicine, University of Colorado, Aurora, Colorado, USA

7. Denver VA Medical Center, Aurora, Colorado, USA

Abstract

Although rare, WNV encephalitis poses a devastating health concern, with few treatment options and frequent long-term neurological sequelae. Currently, there are no human vaccines or specific antivirals against WNV infections, so further research into potential new therapeutic agents is critical.

Funder

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01805-22

Reference75 articles.

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2. Caspase 3-Dependent Cell Death of Neurons Contributes to the Pathogenesis of West Nile Virus Encephalitis

3. Death Receptor-Mediated Apoptotic Signaling Is Activated in the Brain following Infection with West Nile Virus in the Absence of a Peripheral Immune Response

4. Neuroinflammation in the central nervous system: Symphony of glial cells

5. Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

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