Depletion of Complement Enhances the Clearance of Brucella abortus in Mice-Reference-Cited by-同舟云学术

Depletion of Complement Enhances the Clearance of Brucella abortus in Mice

Published:2018-10 Issue:10 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

González-Espinoza Gabriela¹,Barquero-Calvo Elías²^ORCID,Lizano-González Esteban¹,Alfaro-Alarcón Alejandro³,Arias-Gómez Berny¹,Chaves-Olarte Esteban¹,Lomonte Bruno⁴,Moreno Edgardo²⁵,Chacón-Díaz Carlos¹^ORCID

Affiliation:

1. Centro de Investigación en Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

2. Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica

3. Departamento de Patología, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica

4. Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

5. Programa de Maestría en Microbiología, Química Clínica y Parasitología, Sistema de Estudios de Posgrado, Universidad de Costa Rica, San José, Costa Rica

Abstract

Brucellosis is a bacterial disease of animals and humans. Brucella abortus barely activates the innate immune system at the onset of infection, and this bacterium is resistant to the microbicidal action of complement.

Funder

Rectoria Universidad de Costa Rica

International Centre for Genetic Engineering and Biotechnology

UCR | Vicerrectoría de Investigación, Universidad de Costa Rica

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00567-18

Reference35 articles.

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2. Brucella abortus Uses a Stealthy Strategy to Avoid Activation of the Innate Immune System during the Onset of Infection

3. An evolutionary strategy for a stealthy intracellular Brucella pathogen

4. Neutrophils Exert a Suppressive Effect on Th1 Responses to Intracellular Pathogen Brucella abortus

5. Brucella canis Is an Intracellular Pathogen That Induces a Lower Proinflammatory Response than Smooth Zoonotic Counterparts

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