Dietary Polyunsaturated Fatty Acids Promote Neutrophil Accumulation in the Spleen by Altering Chemotaxis and Delaying Cell Death-Reference-Cited by-同舟云学术

Dietary Polyunsaturated Fatty Acids Promote Neutrophil Accumulation in the Spleen by Altering Chemotaxis and Delaying Cell Death

Published:2019-08 Issue:8 Volume:87 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Svahn Sara L.¹^ORCID,Gutiérrez Saray¹,Ulleryd Marcus A.¹,Nookaew Intawat²³,Osla Veronica⁴,Beckman Fredrik¹,Nilsson Staffan⁵⁶,Karlsson Anna⁴^ORCID,Jansson John-Olov¹,Johansson Maria E.¹^ORCID

Affiliation:

1. Department of Physiology, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

2. Department of Biomedical Informatics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

3. Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

4. Department of Rheumatology and Inflammation, Institute of Medicine, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

5. Department of Mathematical Statistics, Chalmers University of Technology, Gothenburg, Sweden

6. Department of Pathology and Genetics, Institute of Biomedicine, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

Abstract

Neutrophils are the most abundant circulating leukocytes in humans and are essential for the defense against invading pathogens. Like many other cells of an organism, neutrophils can be highly influenced by the diet. We have previously described that mice fed a high-fat diet rich in polyunsaturated fatty acids (HFD-P) present a higher frequency of neutrophils in bone marrow than mice fed a high-fat diet rich in saturated fatty acids (HFD-S).

Funder

Swedish Research Council

Swedish Society of Medicine

Sahlgrenska Center for Cardiovascular and Metabolic Research

Adlerbertska Stiftelserna

Magnus Bergvalls Stiftelse

Stiftelserna Wilhelm och Martina Lundgrens

EC | Seventh Framework Programme

Åke Wiberg Stiftelse

Stiftelsen Längmanska Kulturfonden

Stiftelsen Lars Hiertas Minne

Stiftelsen Tornspiran