Author:
Stiller R L,Bennett J E,Scholer H J,Wall M,Polak A,Stevens D A
Abstract
Candida albicans isolates from 402 patients with no prior history of treatment with 5-fluorocytosine were collected at five medical centers from different areas of the United States. Isolates could be separated into four groups based on their minimum inhibitory concentrations (MICs) to 5-fluorocytosine. Group I isolates (60%) had MICs less than or equal to 12.5 micrograms/ml after 7 days, whereas groups II (22%), III (14%), and IV (4%) demonstrated MICs greater than 12.5 micrograms/ml on days 7, 2, and 1, respectively. Serotypes A and B accounted for 50.7 and 49.3%, respectively, of the 398 isolates typed. Serotype B was less prevalent in group I (26%), but predominated in the more resistant groups, groups II (85%), III (86%), and IV (53%). The common practice of identifying as "resistant" those isolates with MICs greater than 12.5 micrograms/ml after 48 h of incubation would yield a resistance rate in the United States of 11.5 to 15.5% in four centers and 35% in the fifth. Although serotype B and small agar disk diffusion zone sizes correlated with poor 5-fluorocytosine susceptibility, their ability to predict tube dilution MICs was limited. The true predictive value of such tests awaits correlation with in vivo studies.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference20 articles.
1. A study of 666 strains of Candida albicans: correlation between serotype and susceptibility to 5-fluorocytosine;Auger P.;J. Infect. Dis. 139-.590-594.,1979
2. Bennett , J. E. 1977 . Flucytosine. Ann. Intern. Med. 86 : 319 - 322 .
3. Recherches sur les serotypes A et B de C. albicans;Drouhet E.;Bull. Soc. Fr. Mycol. Med.,1971
4. Sensibilite et resistance des levures pathogenes aux 5- fluoropyrimidines. I. Relation entre les phenotypes de resistance a la 5-fluorocytosine, le serotype de Candida albicans et l'6cologie de differentes especes de Candida d'origine humaine;Drouhet E.;Ann. Microbiol. (Paris),1975
5. Severe candidal infections. Clinical perspective, immune defense mechanisms, and current concepts of therapy;Edwards J. E.;Ann. Intern. Med.,1978
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