Population Structure and Genetic Diversity among Isolates of Coccidioides posadasii in Venezuela and Surrounding Regions-Reference-Cited by-同舟云学术

Population Structure and Genetic Diversity among Isolates of Coccidioides posadasii in Venezuela and Surrounding Regions

Published:2019-12-24 Issue:6 Volume:10 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Teixeira Marcus M.¹²³,Alvarado Primavera⁴,Roe Chandler C.¹²^ORCID,Thompson George R.⁵,Patané José S. L.⁶,Sahl Jason W.²,Keim Paul¹²^ORCID,Galgiani John N.⁷^ORCID,Litvintseva Anastasia P.⁸,Matute Daniel R.⁹,Barker Bridget M.¹²^ORCID

Affiliation:

1. The Translational Genomics Research Institute (TGen)—Affiliate of City of Hope, Flagstaff, Arizona, USA

2. Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, Arizona, USA

3. Núcleo de Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil

4. Servicio Autonomo Instituto de Biomedicina Dr. Jacinto Convit, Caracas, Venezuela

5. Departments of Medicine, Division of Infectious Diseases, and Medical Microbiology and Immunology, UC Davis Medical Center, Sacramento, California, USA

6. Laboratório Especial de Ciclo Celular, Instituto Butantan, São Paulo, Brazil

7. Valley Fever Center for Excellence, University of Arizona College of Medicine, Tucson, Arizona, USA

8. Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

9. Department of Biology, University of North Carolina, Chapel Hill, North Carolina, USA

Abstract

Valley Fever is a fungal disease caused by two species of fungi: Coccidioides immitis and C. posadasii . These fungi are found throughout the arid regions of North and South America; however, our understanding of genetic diversity and disease in South America is limited. In this report, we analyze 10 new genomes of Coccidioides posadasii from regions bordering the Caribbean Sea. We show that these populations are distinct and that isolates from Venezuela are likely a result of a recent bottleneck. These data point to patterns that might be observed when investigating recently established populations.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01976-19

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