Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells-Reference-Cited by-同舟云学术

Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Garcia-Rubio Rocio¹,Jimenez-Ortigosa Cristina¹,DeGregorio Lucius¹,Quinteros Christopher¹,Shor Erika¹²^ORCID,Perlin David S.¹²³

Affiliation:

1. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

2. Department of Medical Sciences, Hackensack Meridian Health School of Medicine, Nutley, New Jersey, USA

3. Lombardi Comprehensive Cancer Center, Department of Microbiology and Immunology, Georgetown University, Washington, DC, USA

Abstract

Echinocandin drugs are a first-line therapy to treat invasive candidiasis, which is a major source of morbidity and mortality worldwide. The opportunistic fungal pathogen Candida glabrata is a prominent bloodstream fungal pathogen, and it is notable for rapidly developing echinocandin-resistant strains associated with clinical failure.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01959-21

Reference70 articles.

1. Invasive candidiasis

2. The Changing Epidemiology of Invasive Fungal Infections

3. Current perspectives on echinocandin class drugs