Mucosal Bacteria Modulate Candida albicans Virulence in Oropharyngeal Candidiasis-Reference-Cited by-同舟云学术

Mucosal Bacteria Modulate Candida albicans Virulence in Oropharyngeal Candidiasis

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Bertolini M.¹^ORCID,Vazquez Munoz R.¹,Archambault L.¹^ORCID,Shah S.²,Souza J. G. S.³⁴^ORCID,Costa R. C.⁵,Thompson A.¹,Zhou Y.⁶,Sobue T.¹,Dongari-Bagtzoglou A.¹

Affiliation:

1. Department of Oral Health and Diagnostic Sciences, UConn Health, Farmington, Connecticut, USA

2. Department of Computer Science and Engineering, University of Connecticut, Storrs, Connecticut, USA

3. Dental Research Division, Guarulhos University, Guarulhos, SP, Brazil

4. Dental Science School (Faculdade de Ciências Odontológicas [FCO]), Montes Claros, MG, Brazil

5. Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil

6. Department of Medicine, UConn Health, Connecticut, Farmington, Connecticut, USA

Abstract

By comparing Candida albicans virulence and the mucosal bacterial composition in a mouse oral infection model, we were able to dissect the effects of the host environment (immunosuppression), infection with C. albicans , and local modulating factors (availability of sucrose as a carbon source) on the mucosal bacterial microbiome and its role on fungal virulence. We showed that changes in endogenous microbial communities in response to sucrose can lead to attenuation of fungal disease.

Funder

HHS | NIH | National Institute of Dental and Craniofacial Research

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.01937-21

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