Natural Inhibitor of Human Cytomegalovirus in Human Seminal Plasma-Reference-Cited by-同舟云学术

Natural Inhibitor of Human Cytomegalovirus in Human Seminal Plasma

Published:2019-03-15 Issue:6 Volume:93 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lippold Sina¹,Braun Berenike¹,Krüger Franziska²,Harms Mirja²,Müller Janis A.²,Groß Rüdiger²,Münch Jan²³,von Einem Jens¹

Affiliation:

1. Institute of Virology, Ulm University Medical Center, Ulm, Germany

2. Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany

3. Core Facility Functional Peptidomics, Ulm University Medical Center, Ulm, Germany

Abstract

The role of semen in sexual transmission of human cytomegalovirus (HCMV) is currently unclear. This is surprising, as HCMV is frequently detected in this body fluid and infection is of high danger for neonates and pregnant women. In this study, we found that seminal plasma (SP) dose dependently inhibited HCMV infection. The infection inhibition was specific for HCMV, as other viruses, such as human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus 2 (HSV-2), were not inhibited by SP. SP must contain a soluble, heat-resistant factor that limits attachment of HCMV particles to cells, probably by interaction with the trimeric glycoprotein complex gH/gL/gO. This novel virus-host interaction could possibly limit transmission of HCMV via semen during sexual intercourse.

Funder

International Graduate School in Molecular Medicine Ulm

Deutsche Forschungsgemeinschaft

Baden-Württemberg Stiftung

Volkswagen Foundation

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01855-18

Reference52 articles.