Perillyl Alcohol Reduces Parasite Sequestration and Cerebrovascular Dysfunction during Experimental Cerebral Malaria-Reference-Cited by-同舟云学术

Perillyl Alcohol Reduces Parasite Sequestration and Cerebrovascular Dysfunction during Experimental Cerebral Malaria

Published:2021-04-19 Issue:5 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Marin Adriana A.¹,Murillo Oscar¹,Sussmann Rodrigo A.¹,Ortolan Luana S.²,Battagello Daniella S.³,de Castro Quirino Thatyane⁴,Bittencourt Jackson C.³,Epiphanio Sabrina⁴,Katzin Alejandro M.¹^ORCID,Carvalho Leonardo J. M.⁵

Affiliation:

1. Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil

2. Department of Immunology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil

3. Department of Anatomy, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil

4. Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil

5. Laboratory of Malaria Research, Oswaldo Cruz Institute, Rio de Janeiro, Brazil

Abstract

Cerebral malaria (CM) is a severe immune vasculopathy which presents a high mortality rate (15 to 20%), despite the availability of artemisinin-based therapy. More effective immunomodulatory and/or antiparasitic therapies are urgently needed.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00004-21

Reference65 articles.

1. Burden, Features, and Outcome of Neurological Involvement in Acute Falciparum Malaria in Kenyan Children

2. Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection

3. Cerebral Malaria in Children Is Associated With Long-term Cognitive Impairment