Extracellular Vesicle Formation in Cryptococcus deuterogattii Impacts Fungal Virulence and Requires the <i>NOP16</i> Gene-Reference-Cited by-同舟云学术

Extracellular Vesicle Formation in Cryptococcus deuterogattii Impacts Fungal Virulence and Requires the NOP16 Gene

Published:2022-08-18 Issue:8 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Castelli Rafael F.¹²,Pereira Alana³,Honorato Leandro⁴,Valdez Alessandro⁴,de Oliveira Haroldo C.¹,Bazioli Jaqueline M.³⁵,Garcia Ane W. A.⁶,Klimeck Tabata D’Maiella Freitas¹,Reis Flavia C. G.¹⁷,Staats Charley C.⁶,Nimrichter Leonardo⁴^ORCID,Fill Taícia P.³,Rodrigues Marcio L.¹⁴^ORCID

Affiliation:

1. Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil

2. Programa de Pós-Graduação em Biologia Parasitária, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil

3. Instituto de Química, Universidade de Campinas, São Paulo, Brazil

4. Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

5. Faculty of Pharmaceutical Sciences, State University of Campinas, Campinas, São Paulo, Brazil

6. Programa de Pós-graduação em Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

7. Centro de Desenvolvimento Tecnológico em Saúde (CDTS), Fundação Oswaldo Cruz, Rio de Janeiro, Brazil

Abstract

Small molecules are components of fungal extracellular vesicles (EVs), but their biological roles are only superficially known. NOP16 is a eukaryotic gene that is required for the activity of benzimidazoles against Cryptococcus deuterogattii . In this study, during the phenotypic characterization of C. deuterogattii mutants lacking NOP16 expression, we observed that this gene was required for EV production.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00232-22

Reference45 articles.

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