Seneca Valley Virus Enters PK-15 Cells via Caveolae-Mediated Endocytosis and Macropinocytosis Dependent on Low-pH, Dynamin, Rab5, and Rab7

Author:

Hou Lei12,Tong Xinxin3,Pan Yang3,Shi Ruihan4,Liu Changzhe12,Guo Jinshuo12,Shi Yongyan12,Yang Xiaoyu12,Wang Yong3,Feng Xufei12,Zhou Jianwei12,Liu Jue12ORCID

Affiliation:

1. College of Veterinary Medicine, Yangzhou University, Yangzhou, China

2. Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China

3. College of Animal Science and Technology, Anhui Agricultural University, Hefei, China

4. Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing, China

Abstract

Entry of virus into cells represents the initiation of a successful infection. As an emerging pathogen of porcine vesicular disease, clarification of the process of SVV entry into cells enables us to better understand the viral life cycle and pathogenesis.

Funder

Introduction Program of High-Level Innovation and Entrepeneurship Talents in Jiangsu Province

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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