Zika Virus Infection Induced Apoptosis by Modulating the Recruitment and Activation of Proapoptotic Protein Bax-Reference-Cited by-同舟云学术

Zika Virus Infection Induced Apoptosis by Modulating the Recruitment and Activation of Proapoptotic Protein Bax

Published:2021-03-25 Issue:8 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Han Xiaodong¹,Wang Jiuqiang²,Yang Yang³,Qu Shuxiang¹,Wan Fang¹,Zhang Ziyi¹,Wang Ruigang¹,Li Guojing¹,Cong Haolong³⁴

Affiliation:

1. College of Life Sciences, Inner Mongolia Agriculture University, Hohhot, People’s Republic of China

2. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People’s Republic of China

3. Chinese Academy of Inspection and Quarantine, Beijing, People’s Republic of China

4. Center for Molecular Virology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of China

Abstract

Since the large outbreaks that occurred in the Pacific Islands and Latin America in 2013, Zika virus has been confirmed a neuroteratogenic pathogen and causative agent of microcephaly and other developmental anomalies of the central nervous system in children born to infected mothers. As apoptosis is widespread throughout the whole brain, studies in animal models have reinforced the link between microcephaly caused by ZIKV infection and neural progenitor cell (NPC) apoptosis. Currently, the detailed mechanism of ZIKV infection-induced apoptosis still remains to be elucidated.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01445-20

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