Acanthamoeba polyphaga Mimivirus Prevents Amoebal Encystment-Mediating Serine Proteinase Expression and Circumvents Cell Encystment

Author:

Boratto Paulo,Albarnaz Jonas Dutra,Almeida Gabriel Magno de Freitas,Botelho Lucas,Fontes Alide Caroline Lima,Costa Adriana Oliveira,Santos Daniel de Assis,Bonjardim Cláudio Antônio,La Scola Bernard,Kroon Erna Geessien,Abrahão Jônatas Santos

Abstract

Acanthamoebais a genus of free-living amoebas distributed worldwide. Few studies have explored the interactions between these protozoa and their infecting giant virus,Acanthamoeba polyphagamimivirus (APMV). Here we show that, once the amoebal encystment is triggered, trophozoites become significantly resistant to APMV. Otherwise, upon infection, APMV is able to interfere with the expression of a serine proteinase related to amoebal encystment and the encystment can no longer be triggered.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference13 articles.

1. Free-living amoebae as opportunistic and non-opportunistic pathogens of humans and animals;Int J Parasitol,2004

2. Microbiome of free-living amoebae isolated from drinking water;Water Res,2013

3. Acanthamoeba spp. as agents of disease in humans;Clin Microbiol Rev,2003

4. Acanthamoeba, naturally intracellularly infected with Pseudomonas aeruginosa, after their isolation from a microbiologically contaminated drinking water system in a hospital;Zentralbl Hyg Umweltmed,1995

5. Survival of Coxiella burnetii within free-living amoeba Acanthamoeba castellanii;Clin Microbiol Infect,2001

Cited by 17 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3