The Phenolic Diterpene Totarol Inhibits Multidrug Efflux Pump Activity in Staphylococcus aureus-Reference-Cited by-同舟云学术

The Phenolic Diterpene Totarol Inhibits Multidrug Efflux Pump Activity in Staphylococcus aureus

Published:2007-12 Issue:12 Volume:51 Page:4480-4483
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Smith Eileen C. J.¹,Kaatz Glenn W.²³,Seo Susan M.³,Wareham Neale⁴,Williamson Elizabeth M.⁵,Gibbons Simon¹

Affiliation:

1. Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom

2. The John D. Dingell Department of Veteran's Affairs Medical Centre

3. Department of Internal Medicine, Division of Infectious Diseases, School of Medicine, Wayne State University, Detroit, Michigan 48201

4. Stiefel International R&D, Whitebrook Park, 68 Lower Cookham Road, Maidenhead, Berkshire SL6 8XY, United Kingdom

5. Department of Pharmacy, University of Reading, Whiteknights, Reading, Berks RG6 6AJ, United Kingdom

Abstract

ABSTRACT The phenolic diterpene totarol had good antimicrobial activity against effluxing strains of Staphylococcus aureus . Subinhibitory concentrations reduced the MICs of selected antibiotics, suggesting that it may also be an efflux pump inhibitor (EPI). A totarol-resistant mutant that overexpressed norA was created to separate antimicrobial from efflux inhibitory activity. Totarol reduced ethidium efflux from this strain by 50% at 15 μM (1/4× MIC), and combination studies revealed marked reductions in ethidium MICs. These data suggest that totarol is a NorA EPI as well as an antistaphylococcal antimicrobial agent.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00216-07

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