Restricted Isotypic Antibody Reactivity to Hepatitis C Virus Synthetic Peptides in Immunocompromised Patients-Reference-Cited by-同舟云学术

Restricted Isotypic Antibody Reactivity to Hepatitis C Virus Synthetic Peptides in Immunocompromised Patients

Published:1999-03 Issue:2 Volume:6 Page:279-281
ISSN:1071-412X
Container-title:Clinical Diagnostic Laboratory Immunology
language:en
Short-container-title:Clin Diagn Lab Immunol

Author:

Devesa Marisol¹,de Saez Arlette²,León Graciela²,Sirit Firelei³,Cosson Clarisa¹,Bermúdez Henry⁴,Liprandi Ferdinando¹,Noya Oscar⁴,Pujol Flor H.¹

Affiliation:

1. Laboratorio de Biologı́a de Virus, Centro de Microbiologı́a y Biologı́a Celular,1 and

2. Banco Municipal de Sangre,2 and

3. Planta Procesadora de Derivados Sanguı́neos, Quimbiotec,3Instituto Venezolano de Investigaciones Cientı́ficas,

4. Laboratorio de Sı́ntesis de Péptidos, Sección de Biohelmintiasis, Instituto de Medicina Tropical, Universidad Central de Venezuela,4 Caracas, Venezuela

Abstract

ABSTRACT An enzyme immunoassay based on three synthetic peptides from the core, NS4, and NS5 regions of hepatitis C virus allowed the detection of antibodies in 100% of immunocompetent infected patients and in 91% of immunocompromised patients (hemodialysis and hemophiliac patients). Immune impairment seemed to restrict the spectrum of antibody isotypes reacting to the core peptide.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CDLI.6.2.279-281.1999

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