Inhibition of Duck Hepatitis B Virus Infection by a Myristoylated Pre-S Peptide of the Large Viral Surface Protein-Reference-Cited by-同舟云学术

Inhibition of Duck Hepatitis B Virus Infection by a Myristoylated Pre-S Peptide of the Large Viral Surface Protein

Published:2002-02-15 Issue:4 Volume:76 Page:1986-1990
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Urban Stephan¹,Gripon Philippe²

Affiliation:

1. Zentrum für Molekulare Biologie, Universität Heidelberg (ZMBH), 69120 Heidelberg, Germany

2. Régulation des Equilibres Fonctionnels du Foie Normal et Pathologique U 522, Institut National de la Santé et de la Recherche Médicale, Hôpital de Pontchaillou, 35033 Rennes Cedex, France

Abstract

ABSTRACT We have used the duck hepatitis B virus (DHBV) model to study the interference with infection by a myristoylated peptide representing an N-terminal pre-S subdomain of the large viral envelope protein. Although lacking the essential part of the carboxypeptidase D (formerly called gp180) receptor binding site, the peptide binds hepatocytes and subsequently blocks DHBV infection. Since its activity requires an amino acid sequence involved in host discrimination between DHBV and the related heron HBV (T. Ishikawa and D. Ganem, Proc. Natl. Acad. Sci. USA 92:6259-6263, 1995), we suggest that it is related to the postulated host-discriminating cofactor of infection.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.76.4.1986-1990.2002

Reference22 articles.

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4. Gripon, P., J. Le Seyec, S. Rumin, and C. Guguen-Guillouzo. 1995. Myristylation of the hepatitis B virus large surface protein is essential for viral infectivity. Virology 213 : 292-299.

5. Ishikawa, T., K. Kuroki, R. Lenhoff, J. Summers, and D. Ganem. 1994. Analysis of the binding of a host cell surface glycoprotein to the pre-S protein of duck hepatitis B virus. Virology 202 : 1061-1064.

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