Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex-Reference-Cited by-同舟云学术

Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex

Published:2022-09-14 Issue:17 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wick Elizaveta T.¹²,Treadway Colton J.¹²,Li Zhijun³²,Nicely Nathan I.¹,Ren Zhizhong³²,Baldwin Albert S.²,Xiong Yue³²,Harrison Joseph S.⁴^ORCID,Brown Nicholas G.¹²^ORCID

Affiliation:

1. Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina, USA

2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

3. Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina, USA

4. Department of Chemistry, University of the Pacific, Stockton, California, USA

Abstract

Many different viruses modulate the protein machinery required for ubiquitination to enhance viral fitness. Specifically, several viruses hijack the cullin-RING ligase CRL4 DDB1 to degrade host resistance factors.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

HHS | National Institutes of Health

U.S. Department of Energy

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00826-22