Ex Vivo and In Vivo CD46 Receptor Utilization by Species D Human Adenovirus Serotype 26 (HAdV26)-Reference-Cited by-同舟云学术

Ex Vivo and In Vivo CD46 Receptor Utilization by Species D Human Adenovirus Serotype 26 (HAdV26)

Published:2022-02-09 Issue:3 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hemsath Jack R.¹^ORCID,Liaci A. Manuel²³,Rubin Jeffrey D.⁴,Parrett Brian J.⁴,Lu Shao-Chia⁴,Nguyen Tien V.⁵,Turner Mallory A.⁴,Chen Christopher Y.⁵,Cupelli Karolina²,Reddy Vijay S.⁶,Stehle Thilo²^ORCID,Liszewski M. Kathryn⁷,Atkinson John P.⁷,Barry Michael A.⁵⁸⁹^ORCID

Affiliation:

1. Graduate Research Employee Program, Mayo Clinic, Rochester, Minnesota, USA

2. Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany

3. Structural Biochemistry, Bijvoet Centre for Biomolecular Research, Utrecht University, Utrecht, The Netherlands

4. Virology and Gene Therapy Graduate Program, Mayo Clinic, Rochester, Minnesota, USA

5. Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA

6. Department of Integrative Structural and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA

7. Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

8. Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA

9. Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, USA

Abstract

The human species D Ad26 is being investigated as a low-seroprevalence vector for oncolytic virotherapy and gene-based vaccination against HIV-1 and SARS-CoV-2. However, there is debate in the literature about its tropism and receptor utilization, which directly influence its efficiency for certain applications. This work was aimed at determining which receptor(s) this virus uses for infection and its role in virus biology, vaccine efficacy, and, importantly, vaccine safety.

Funder

University of Iowa/Mayo Clinic Lymphoma Specialized Program of Research Excellence (SPORE) in Lymphoma

HHS | NIH | National Institute of General Medical Sciences

Mayo Clinic

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00826-21

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1. Genetic content and evolution of adenoviruses